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An age-dependent increase the glycoprotein CD38, may contribute to cellular NAD + depletion and impaired mitochondrial function

However, a small fraction of APAP undergoes oxidative metabolism by cytochrome P450 enzymes, predominantly cytochrome P450 2E1 (CYP2E1), to form N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive and toxic intermediate

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